| Missouri Southern State Lions Football vs. Midwestern State Mustangs | 8-30-2025
Saturday
TBD | Fred G. Hughes Stadium in Joplin, MO | View Tickets |
| Missouri Southern State Lions Football vs. Northwest Missouri State Bearcats | 9-20-2025
Saturday
TBD | Fred G. Hughes Stadium in Joplin, MO | View Tickets |
| Central Missouri Mules Football vs. Missouri Southern State Lions | 9-27-2025
Saturday
TBD | Kennedy Field At Audrey J. Walton Stadium in Warrensburg, MO | View Tickets |
| Missouri Southern State Lions Football vs. Fort Hays State Tigers | 10-7-2025
Tuesday
TBD | Fred G. Hughes Stadium in Joplin, MO | View Tickets |
| Emporia State Hornets Football vs. Missouri Southern State Lions | 10-11-2025
Saturday
TBD | Welch Stadium in Emporia, KS | View Tickets |
| Missouri Southern State Lions Football vs. Washburn Ichabods | 10-15-2025
Wednesday
TBD | Fred G. Hughes Stadium in Joplin, MO | View Tickets |
| Missouri Southern State Lions Football vs. Nebraska-Kearney Lopers | 10-18-2025
Saturday
TBD | Fred G. Hughes Stadium in Joplin, MO | View Tickets |
| Missouri Southern State Lions Football vs. Missouri Western Griffons | 10-25-2025
Saturday
TBD | Fred G. Hughes Stadium in Joplin, MO | View Tickets |
| Pittsburg State Gorillas Football vs. Missouri Southern State Lions | 11-1-2025
Saturday
TBD | Carnie Smith Stadium in Pittsburg, KS | View Tickets |
| Pittsburg State Gorillas Football vs. Missouri Southern State Lions | 11-1-2025
Saturday
2:00 PM | Carnie Smith Stadium in Pittsburg, KS | View Tickets |
| Central Oklahoma Bronchos Football vs. Missouri Southern State Lions | 11-8-2025
Saturday
1:00 PM | Chad Richison Stadium in Edmond, OK | View Tickets |
